Through chemical synthesis and biophysical
evaluation of DNA-ligand interactions we strive for three primary
1. Develop new tools for probing DNA chemistry and biology.
2. Generate new leads for anti-viral and anti-cancer agents.
3. Create an environment where innovation and education flourish.
We use rational design and synthetic organic chemistry to create compounds with interesting physical properties including fluorescence emission, structure-selective DNA binding, and anti-cancer activity. Our current emphasis is on the development of small molecules that bind to and stabilize non-duplex structures like G-quadruplex and i-motif DNA. We are also developing new photophysical and photochemical methods to probe DNA folding and to synthesize well-defined DNA-DNA interstrand cross links.
Research efforts in our group are divided almost 50:50 between synthetic chemistry and biophysics/cell biology/molecular biology. Post-doctoral coworkers should have completed a Ph.D. program in a relevant area. Those scientists that can bring their own financial support through a grant-awarding institution are particularly welcome. Please submit your application by email or post to Nathan Luedtke.
Where to Find Us
We located on the Irchel-Campus of the University, see: map.search.ch. The Campus is easily reached by public transportation. Take tram 7,9,10,14 or bus 69,72 to either the Irchel or Milchbuck stop. Travel plans and time tables for these trams and buses are available at: Verkehrsbetriebe Zurich.
Once you are here, you can identify our buildings on the campus-map. We are in buildings 32 and 11. Nathan Luedtke's office is in 11-G-15 (building 11, floor G, room 15). The main laboratory is 32-G-68 (building 32, floor G, room 68).
How to Contact Us
- University of Zurich
- Winterthurerstrasse 190
- CH-8057 Zurich
By phone or email:
- Proceed to our people page for the phone numbers and email addresses of individual group members.
+41 44 635 68 91