The Group



Our Mission

Through chemical synthesis and biological evaluation of modified nucleosides and nucleotides, we strive for four primary goals:

1. Develop new tools for probing DNA chemistry and biology.

2. Generate new leads for anti-viral and anti-cancer agents.

3. Develop new diagnostic methods for personalized medicine.

4. Create an environment where innovation and education flourish.


Our Approach

We use rational design and synthetic organic chemistry to create compounds with interesting physical properties including fluorescence emission, structure-selective DNA binding, and anti-cancer activity. Our current emphasis is on the development of metabolic labeling strategies for nucleic acids in vivo. We will interface this with new photophysical and photochemical methods to synthesize well-defined DNA-DNA interstrand cross links for medicinal and diagnostic applications.



Positions Available

Research efforts in our group are divided almost 50:50 between synthetic chemistry and biophysics/cell biology/molecular biology. Post-doctoral coworkers should have completed a Ph.D. program in a relevant area. Those scientists that can bring their own financial support through a grant-awarding institution are particularly welcome. Please submit your application by email or post to Nathan Luedtke.



Where to Find Us

We located on the Irchel-Campus of the University, see: The Campus is easily reached by public transportation. Take tram 7,9,10,14 or bus 69,72 to either the Irchel or Milchbuck stop. Travel plans and time tables for these trams and buses are available at: Verkehrsbetriebe Zurich.

Once you are here, you can identify our buildings on the campus-map. We are in buildings 32 and 11. Nathan Luedtke's office is in 11-G-03 (building 11, floor G, room 03). The main laboratory is 32-G-68 (building 32, floor G, room 68).



How to Contact Us


By post:  

  • University of Zurich
  • Winterthurerstrasse 190
  • CH-8057 Zurich

By phone or email:

  • Proceed to our people page for the phone numbers and email addresses of individual group members.

By Fax:

        +41 44 635 68 91