The Group

Our Mission

Through chemical synthesis and biological evaluation of modified nucleosides, nucleotides and oligonucleotides, we strive for four primary goals:

1. Develop new methods for probing DNA and RNA molecules in vivo using fluorescence.

2. Generate new mechanistic understanding and drug candidates for treating leukemia.

3. Develop new diagnostic + therapeutic "theranostic" methods for personalized medicine.

4. Create an inclusive environment where innovation and education flourish.

Our Approach

We use rational design and synthetic organic chemistry to create compounds with interesting physical properties including fluorescence emission, structure-selective DNA/RNA binding, and anti-cancer activity. Our current emphasis is on the development of metabolic labeling strategies for nucleic acids in vivo. We will interface this with new photophysical and photochemical methods for theranostics applications.

Positions Available

Research efforts in our group are divided between synthetic chemistry and biophysics/cell biology/molecular biology. Post-doctoral coworkers should have completed a Ph.D. program in a relevant area. Those scientists that can bring their own financial support through a grant-awarding institution are particularly welcome. New graduate students must apply to the group via a McGill University graduate program in chemistry or pharmacology and therapeutics.


How to Contact Us

By post:  

  • McGill University
  • Department of Chemistry
  • Montreal, Quebec, H3A 0B8, Canada

By phone or email:

  • Proceed to our people page for the phone numbers and email addresses of individual group members.

By Fax:

        +1 514-398-3797