Symmetrical dinuclear complexes with high DNA affinity based on [Ru(dpq)2(phen)]2+
Janice Aldrich-Wright, Craig Brodie, Edith C. Glazer, Nathan W. Luedtke, Lev
Elson-Schwab, and Yitzhak Tor
Abstract
Symmetrical homometallic dinuclear complexes of the type [{Ru(dpq)2}2(phenSOSphen)]4+, with a flexible 2-mercaptoethyl ether linker
joining the two [Ru(dpq)2(phen)]2+-based sub-units, have DNA dissociation
constants (Kd) in the nM range.