Journal Articles

 

1. Synthesis of DNA interstrand crosslinks using a photocaged nucleobase
    S. Hentschel, J. Alzeer, T. Angelov, O. D. Schärer, N. W. Luedtke, Angew. Chemie. 2012, In press.

2. Excitonic luminescence of hemiporphyrazines
    S. M. Huber, M. S. Seyfried, A. Linden, N. W. Luedtke, Inorg. Chem. 2012, Revision requested.

3. Dynamic metabolic labeling of DNA in vivo with arabinosyl nucleosides
    A. B. Neef, N. W. Luedtke, Proc. Natl. Acad. Sci. USA, 2011, DOI 10.1073/pnas.1101125108.

4. Site-specific control of N7-metal coordination in DNA using a fluorescent purine derivative
    A. Dumas, N. W. Luedtke, Chem. Eur. J., 2011,  DOI 10.1002/chem.201102349.

5. Contribution of G-Quadruplex probe design to improved detection of DNA sequences using fluorescence
    J. Ren, J. Wang, J. Wang, N. W. Luedtke, E. Wang, Biosensors Bioelec. 2011, DOI 10.1016/j.bios.2011.10.038.

6. Fluorescence properties of 8-(2-pyridyl)guanine "2PyG" as compared to 2-aminopurine in DNA
    A. Dumas, N. W. Luedtke, ChemBioChem, 2011,  12, 2044.

7. Highly fluorescent guanine mimics for folding and energy transfer studies
    A. Dumas, N. W. Luedtke, Nucleic Acids Res., 2011, 39, 6825.

8. Label-free detection of nucleic acids by turn-ON and turn-OFF G-quadruplex-mediated fluorescence
    J. Ren, H. Qin, J. Wang, N. W. Luedtke, E. Wang, Anal. Bioanal. Chem. 2011, 2763.

9. Cation-mediated energy transfer in G-quadruplexes revealed by an internal fluorescent probe
    A. Dumas, N. W. Luedtke, J. Am. Chem. Soc. 2010,  132, 18004.

10. G-quadruplex-modulated fluorescence detection of potassium in a 3500-fold excess of sodium ions
    H. Qin, J. Ren, J. Wang, N. W. Luedtke, E. Wang, Anal. Chem. 2010, 82, 8356.

11. Multiple-turnover isotopic labeling of Fmoc- and Boc-protected amino acids with oxygen isotopes
    M. S. Seyfried, B. S. Lauber, N. W. Luedtke, Org. Lett., 2010, 12, 104. 

12. pH-Mediated fluorescence and G-quadruplex binding of amido phthalocyanines
    J. Alzeer, N. W. Luedtke, Biochemistry, 2010, 49, 4339.

13. Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes
    M. Paramasivam, A. Membrino, S. Cogoi, J. Alzeer, N. W. Luedtke, L. E. Xodo, Chem. Commun., 2010, 625.

14. Guanidino phthalocyanines as high affinity G-quadruplex fluorescent probes and transcriptional regulators
    J. Alzeer, B. R. Vummidi, P. J. C. Roth, N. W. Luedtke, Angew. Chem. Intl. Ed., 2009, 9362. (English)(German)

15. An efficient two-step synthesis of metal-free phthalocyanines using a zinc(II) template
    J. Alzeer, P. J. C. Roth, N. W. Luedtke, Chem. Commun., 2009, 1970. 

16. Targeting G-quadruplex DNA with Small Molecules
    N. W. Luedtke, Chimia. 2009, 63, 134.

17. Surveying polypeptide and protein domain conformation and association with FlAsH and ReAsH
    N. W. Luedtke, R. J. Dexter, D. B. Fired, A. Schepartz, Nat. Chem. Biol. 2007, 779.

18. Lanthanide-mediated phosphoester hydrolysis and phosphate elimination from phosphopeptides
    N. W. Luedtke, A. Schepartz, Chem. Commun. 2005, 5426.

19. A rapid library screen for tailoring beta-peptide structure and function
    J. A. Kritzer, N. W. Luedtke, E. A. Harker, A. Schepartz, J. Am. Chem. Soc. 2005, 14584.

20. On the electronic structure of ethidium
    N. W. Luedtke, Q. Liu, Y. Tor, Chem. Eur. J. 2005, 495.

21. Chemical biology: innovative solutions for diverse challenges
    J. A. Kritzer, N. W. Luedtke, Chem. Biol. 2005, 617.

22. RNA-selective modification by a platinum(II) complex conjugated to amino- and guanidinoglycosides
    J. Boer, K. F. Blount, N. W. Luedtke, L. Elson-Schwab, Y. Tor, Angew. Chem. Intl. Ed. 2005, 927.

23. Symmetrical dinuclear complexes based on [Ru(dpq)₂(phen)]²⁺ with high DNA affinity
    J. Aldrich-Wright, C. Brodie, E. C. Glazer, N. W. Luedtke, Y. Tor, Chem. Commun. 2004, 1018.

24. Affinity and specificity of aminoglycoside dimers and acridine conjugates to the HIV-1 Rev response element
    N. W. Luedtke, Q. Liu, Y. Tor, Biochemistry, 2003, 11391.  

25. Cellular uptake of aminoglycosides, guanidinoglycosides, and poly-arginine
    N. W. Luedtke, P. Carmichael, Y. Tor, J. Am. Chem. Soc., 2003, 12374.

26. Fluorescence-based methods for evaluating the RNA affinity and specificity of HIV-1 Rev-RRE inhibitors
    N. W. Luedtke, Y. Tor, Biopolymers, 2003, 103.

27. The DNA and RNA specificity of eilatin Ru(II) complexes as compared to eilatin and ethidium
    N. W. Luedtke, J. S. Hwang, E. C. Glazer, D. Gut, M. Kol, Y. Tor, Nucleic Acids Res., 2003, 5732.  

28. Synthesis, photophysical properties, and nucleic acid binding of phenanthridinium derivatives of ethidium
    N. W. Luedtke, Q. Liu, Y. Tor, Bioorg. Med. Chem., 2003, 5235.  

29. Inhibition of nuclear import mediated by the Rev-arginine rich motif by RNA molecules
    K. Fineberg, T. Fineberg, A. Graessmann, N. Luedtke, Y. Tor, D. Jans, A. Loyter, Biochemistry, 2003, 2625.

30. Eilatin Ru(II) complexes display anti-HIV activity and enantiomeric diversity in the binding of RNA
    N. W. Luedtke, J. S. Hwang, E. C. Glazer, D. Gut, M. Kol, Y. Tor, Chembiochem, 2002, 766.

31. 2-Aminopurine as a real-time probe of enzymatic cleavage and inhibition of hammerhead ribozymes
    S. R. Kirk, N. W. Luedtke, Y. Tor, Bioorg. Med. Chem., 2001, 2295.

32. A simple conversion of amines into monosubstituted ureas in organic and aqueous solvents
    Q. Liu, N. W. Luedtke, Y. Tor, Tetrahedron Lett., 2001, 1445.

33. Development of a functional backbone cyclic mimetic of the HIV-1 Tat arginine-rich motif
    A. Friedler, D. Friedler, N. W. Luedtke, Y. Tor, A. Loyter, C. Gilon,  J. Biol. Chem., 2000, 23783.

34. Guanidinoglycosides: A novel family of RNA ligands
    N. W. Luedtke, T. J. Baker, M. Goodman, Y. Tor, J. Am. Chem. Soc., 2000, 12035.

35. A novel solid-phase assembly for identifying potent and selective RNA ligands
    N. W. Luedtke, Y. Tor, Angew. Chem. Intl. Ed., 2000, 1788.  

36. Neomycin-acridine conjugate: A potent inhibitor of Rev-RRE binding
      S. R. Kirk, N. W. Luedtke, Y. Tor, J. Am. Chem. Soc., 2000, 980.

37. Synthesis and anti-HIV activity of guanidinoglycosides
    T. J. Baker, N. W. Luedtke, Y. Tor, M. Goodman, J. Org. Chem., 2000, 9054.

38. The 5'-GNC preference for mustard cross-linking is preserved in a restriction fragment
    J. T. Millard, N. W. Luedtke, R. J. Spencer, Anti-Cancer Drug Des., 1996, 485.      

 

Book Chapter  

1.  Targeting HIV RNA with Small Molecules. In: DNA and RNA Binders Vol. 1
    N. W. Luedtke, Y. Tor, 2002, Wiley-VCH, 18-40.

 

Patents

1. Arabinofuranosyl pyrimidine derivatives for incorporation of bioorthoginal functional groups into DNA 
    N. W. Luedtke, A. B. Neef, 2011, PCT/EP application 11187971.

2. Preparation and uses of guanidinium-modified porphyrins and phthalocyanines
    N. W. Luedtke, J. Alzeer, B. R. Vummidi, 2010, PCT Intl. Appl. WO2010028780.  

3. 8- and 6,8-substituted 2'-deoxyguanosines and uses thereof
    N. W. Luedtke and A. D. Dumas, 2010, PCT Intl. Appl. WO2010028781.

4. Preparation of phenanthridine derivatives as anti-viral agents
    Y. Tor and N. W. Luedtke, 2005, PCT Intl. Appl.WO2005016343.

5. Guanidinium derivatives for improved cellular transport
    Y. Tor and N. W. Luedtke, 2005, PCT Intl. Appl. WO2005025513.

6. Guanidinylation, guanidinoglycosides, uses, and methods of assaying their activity
    M. Goodman, Y. Tor, T. Baker, and N. W. Luedtke, 2003, U.S. 6,525,182 and 6,833,445.

 

Doctoral Theses

        RNA Affinity and Specificity of Modified Aminoglycosides, Metal Complexes, and Intercalating Agents
             Nathan W. Luedtke, University of California, San Diego, 2003.

        8-Substituted-2’-Deoxyguanosines as Internal Probes for DNA Folding and Energy Transfer
             Anaelle Dumas, University of Zurich, Switzerland, 2011.

 

Diplom Thesis

        Synthesis and Evaluation of Guanidino Phthalocyanines for G-quadruplex Binding
             Phillipe J. C. Roth, Institute of Organic Chemistry, University of Zurich, 2008.

 

Masters' Thesis

        Synthesis and Evaluation of Cationic Phthalocyanines as G-quadruplex Ligands
             Raul Geraldo Pereira, Institute of Organic Chemistry, University of Zurich, 2011.