Journal Articles

1.  Electrostatic interactions in phthalocyanine-quadruplex binding.
    J. Alzeer, N. W. Luedtke, Biochemistry, 2010, Revision requested.

2.  Multiple-turnover isotopic labeling of Fmoc- and Boc-protected amino acids with oxygen isotopes.
    M. S. Seyfried, B. S. Lauber, N. W. Luedtke, Org. Lett., 2010, 12, 104. 

3.  Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes.
    M. Paramasivam, A. Membrino, S. Cogoi, J. Alzeer, N. W. Luedtke, L. E. Xodo, Chem. Commun., 2010, 625.

4.  Guanidino phthalocyanines as high affinity G-quadruplex fluorescent probes and transcriptional regulators.
    J. Alzeer, B. R. Vummidi, P. J. C. Roth, N. W. Luedtke, Angew. Chem. Intl. Ed., 2009, 9362. (English)(German)

5.  An efficient two-step synthesis of metal-free phthalocyanines using a zinc(II) template.
    J. Alzeer, P. J. C. Roth, N. W. Luedtke, Chem. Commun., 2009, 1970. 

6.  Targeting G-quadruplex DNA with Small Molecules.
    N. W. Luedtke, Chimia. 2009, 63, 134.

7.  Surveying polypeptide and protein domain conformation and association with FlAsH and ReAsH.
    N. W. Luedtke, R. J. Dexter, D. B. Fired, A. Schepartz, Nat. Chem. Biol. 2007, 779.

8.  Lanthanide-mediated phosphoester hydrolysis and phosphate elimination from phosphopeptides.
    N. W. Luedtke, A. Schepartz, Chem. Commun. 2005, 5426.

9.  A rapid library screen for tailoring beta-peptide structure and function.
    J. A. Kritzer, N. W. Luedtke, E. A. Harker, A. Schepartz, J. Am. Chem. Soc. 2005, 14584.

10.   On the electronic structure of ethidium.
    N. W. Luedtke, Q. Liu, Y. Tor, Chem. Eur. J. 2005, 495.

11.  Chemical biology: innovative solutions for diverse challenges.
    J. A. Kritzer, N. W. Luedtke, Chem. Biol. 2005, 617.

12.  RNA-selective modification by a platinum(II) complex conjugated to amino- and guanidinoglycosides.
    J. Boer, K. F. Blount, N. W. Luedtke, L. Elson-Schwab, Y. Tor, Angew. Chem. Intl. Ed. 2005, 927.

13. Symmetrical dinuclear complexes based on [Ru(dpq)₂(phen)]²⁺ with high DNA affinity.
    J. Aldrich-Wright, C. Brodie, E. C. Glazer, N. W. Luedtke, Y. Tor, Chem. Commun. 2004, 1018.

14. Affinity and specificity of aminoglycoside dimers and acridine conjugates to the HIV-1 Rev response element.
    N. W. Luedtke, Q. Liu, Y. Tor, Biochemistry, 2003, 11391.  

15. Cellular uptake of aminoglycosides, guanidinoglycosides, and poly-arginine.
    N. W. Luedtke, P. Carmichael, Y. Tor, J. Am. Chem. Soc., 2003, 12374.

16. Fluorescence-based methods for evaluating the RNA affinity and specificity of HIV-1 Rev-RRE inhibitors.
    N. W. Luedtke, Y. Tor, Biopolymers, 2003, 103.

17. The DNA and RNA specificity of eilatin Ru(II) complexes as compared to eilatin and ethidium.
    N. W. Luedtke, J. S. Hwang, E. C. Glazer, D. Gut, M. Kol, Y. Tor, Nucleic Acids Res., 2003, 5732.  

18. Synthesis, photophysical properties, and nucleic acid binding of phenanthridinium derivatives of ethidium.
    N. W. Luedtke, Q. Liu, Y. Tor, Bioorg. Med. Chem., 2003, 5235.  

19. Inhibition of nuclear import mediated by the Rev-arginine rich motif by RNA molecules.
    K. Fineberg, T. Fineberg, A. Graessmann, N. Luedtke, Y. Tor, D. Jans, A. Loyter, Biochemistry, 2003, 2625.

20. Eilatin Ru(II) complexes display anti-HIV activity and enantiomeric diversity in the binding of RNA.
    N. W. Luedtke, J. S. Hwang, E. C. Glazer, D. Gut, M. Kol, Y. Tor, Chembiochem, 2002, 766.

21. 2-Aminopurine as a real-time probe of enzymatic cleavage and inhibition of hammerhead ribozymes.
    S. R. Kirk, N. W. Luedtke, Y. Tor, Bioorg. Med. Chem., 2001, 2295.

22. A simple conversion of amines into monosubstituted ureas in organic and aqueous solvents.
    Q. Liu, N. W. Luedtke, Y. Tor, Tetrahedron Lett., 2001, 1445.

23. Development of a functional backbone cyclic mimetic of the HIV-1 Tat arginine-rich motif.
    A. Friedler, D. Friedler, N. W. Luedtke, Y. Tor, A. Loyter, C. Gilon,  J. Biol. Chem., 2000, 23783.

24. Guanidinoglycosides: A novel family of RNA ligands.
    N. W. Luedtke, T. J. Baker, M. Goodman, Y. Tor, J. Am. Chem. Soc., 2000, 12035.

25. A novel solid-phase assembly for identifying potent and selective RNA ligands.
    N. W. Luedtke, Y. Tor, Angew. Chem. Intl. Ed., 2000, 1788.  

26. Neomycin-acridine conjugate: A potent inhibitor of Rev-RRE binding.
    S. R. Kirk, N. W. Luedtke, Y. Tor, J. Am. Chem. Soc., 2000, 980.

27. Synthesis and anti-HIV activity of guanidinoglycosides.
    T. J. Baker, N. W. Luedtke, Y. Tor, M. Goodman, J. Org. Chem., 2000, 9054.

28. The 5'-GNC preference for mustard cross-linking is preserved in a restriction fragment.
    J. T. Millard, N. W. Luedtke, R. J. Spencer, Anti-Cancer Drug Des., 1996, 485.      

 

Book Chapter  

1.  Targeting HIV RNA with Small Molecules. In: DNA and RNA Binders Vol. 1
    N. W. Luedtke, Y. Tor, 2002, Wiley-VCH, 18-40.

 

Patents

1. Preparation and uses of guanidinium-modified porphyrins and phthalocyanines.
    N. W. Luedtke, J. Alzeer, B. R. Vummidi, 2008-2009, PCT/EP application 006417. 

2. 8- and 6,8-substituted 2'-deoxyguanosines and uses thereof.
    N. W. Luedtke and A. D. Dumas, 2008-2009, PCT/EP application 006423.

3. Guanidinylation, guanidinoglycosides, uses, and methods of assaying their activity.
    M. Goodman, Y. Tor, T. Baker, and N. W. Luedtke, 2003, U.S. 6,525,182 and 6,833,445.

4. Preparation of phenanthridine derivatives as anti-viral agents.
    Y. Tor and N. W. Luedtke, 2005, PCT Intl. Appl.WO2005016343.

5. Guanidinium derivatives for improved cellular transport.
    Y. Tor and N. W. Luedtke, 2005, PCT Intl. Appl. WO2005025513.

 

Doctoral Thesis

        RNA Affinity and Specificity of Modified Aminoglycosides, Metal Complexes, and Intercalating Agents.
             N. W. Luedtke PhD Thesis, University of California, San Diego, 2003.