Journal Articles
68. A
highly fluorescent nucleobase molecular rotor
A. Karimi, R. Börner,
G. Mata, N. W. Luedtke, J. Am. Chem. Soc., 2020, doi:
10.1021/jacs.0c05180.
67. Cross-linking
cellular nucleic acids via a target-directing double click reagent
M. Tera, N. W.
Luedtke, Methods Enzymol., 2020, 641, 433.
66. Concerted
dynamics of metallo-base pairs in an A/B-form helical transition
O. P. Schmidt, S.
Jurt, S. Johannsen, A. Karimi, R. K. O. Sigel, N. W. Luedtke, Nat. Commun, 2019,
4818.
65. Enzymatic
incorporation of a coumarin-guanine base pair
A. Johnson, A. Karimi, N. W.
Luedtke, Angew. Chemie Intl. Ed, 2019, 58, 16839.
64. Three
component bioorthogonal chemical reactions on cellular DNA and RNA
M. Tera, N. W.
Luedtke, Bioconjugate Chem, 2019, 30, 2991.
63. Intercalation-enhanced
"click" crosslinking of DNA
M. Tera, Z. H. Taji, N. W.
Luedtke, Angew. Chemie Intl. Ed, 2018, 130, 15631.
62. Incorporation of azide groups into DNA using membrane‐permeable nucleotide triesters in vivo
M. Tera, S. M. K.
Glasauer,
N. W. Luedtke, ChemBioChem,
2018, 19, 1939.
61. HgII
binds to C-T mismatches with high affinity
O. P. Schmidt, A. S. Benz,
G. Mata, N. W. Luedtke, Nucleic Acids Res.,
2018, 46, 6470.
60. Super-resolution
imaging of individual replication forks reveals unexpected prodrug resistance
mechanism
Triemer, Messikommer, Glasauer,
Alzeer, Paulisch, Luedtke, Proc. Natl. Acad. Sci. USA,
2018, 115, E1366.
59. Chemoselective
modification of vinyl DNA by triazolinediones
A. Naik, J. Alzeer, T.
Triemer, N. W. Luedtke, Angew. Chemie Intl. Ed,
2017, 56, 10850.
58. DNA-targeted
inhibition of MGMT
T. Marsoner, O. P. Schmidt,
T. Triemer, N. W. Luedtke, ChemBioChem,
2017, 18, 894.
57. Fluorescent
base analog reveals T-HgII-T base pairs have high kinetic stabilities
that perturb DNA metabolism
O. P. Schmidt, G. Mata, N. W.
Luedtke, J. Am. Chem. Soc.,
2016, 138, 14733.
56. A
fluorescent surrogate of thymidine in duplex DNA
G. Mata, O. P. Schmidt, N. W. Luedtke, Chem. Commun.,
2016, 4718.
55. A bioorthogonal chemical reporter of viral infection
A. B. Neef, L. Pernot, V. N. Schreier, L. Scapozza, N. W. Luedtke, Angew. Chemie. Intl. Ed.
2015, 7911.
54. A
fluorescent probe for proton-coupled folding reveals slow exchange of i-motif and
duplex DNA
G. Mata, N. W. Luedtke, J. Am. Chem. Soc. 2015, 137,
699.
53. Molecular
design and synthesis of a planar telomestatin analog
M. S. Seyfried, J. Alzeer, N. W. Luedtke, Eur.
J. Org. Chem. 2015, DOI: 10.1002/ejoc.201501103.
52. Fluorescent
chemosensors of carbohydrate triols exhibiting TICT emissions
D. Oesch, N. W. Luedtke, Chem. Commun. 2015, 51,
12641.
51. Synthesis of
2-oxazolines by in situ desilylation and cyclodehydration of b-hydroxyamides
Marco Brandstätter, Fabian Roth, N. W.
Luedtke, J. Org. Chem. 2015, 80, 40.
50. Alkene-tetrazine
ligation for imaging of cellular DNA
U. Rieder, N. W.
Luedtke, Angew. Chemie. Intl. Ed. 2014, 53, 9168.
49. An
azide-modified nucleoside for metabolic labeling of DNA
A. B. Neef, N. W.
Luedtke, ChemBioChem 2014, 15, 789.
48. The
influence of extraction solvents on the anticancer activities of palestinian
medicinal plants
J. Alzeer, B. R. Vummidi, R. Arafeh, W. Rimawi, H.
Saleem, N. W. Luedtke, J. Med. Plant Res. 2014, 8, 408.
47. Characterization
of chromosomal architecture in Arabidopsis thaliana by chromosome
conformation capture
S. Grob, M. W.
Schmid, N. W. Luedtke, T. Wicker, U. Grossniklaus, Genome Biol. 2013,
14, R129.
46. Tracking
viral genomes in host cells at single-molecule resolution
I-H. Wang, M.
Suomalainen, V. Andriasyan, S. Kilcher, J. Mercer, A. B. Neef, N. W. Luedtke, U.
F. Greber,
Cell Host
Microbe, 2013, 14, 468.
45. Photodynamic
agents with anti-metastatic activities
B. R. Vummidi, F.
Noreen, J. Alzeer, K. Moelling, N. W. Luedtke, ACS Chem. Biol. 2013,
8, 1737.
44.
Synthesis
and solvatochromic fluorescence of biaryl pyrimidine nucleosides
G. Mata, N. W.
Luedtke, Org. Lett., 2013, 15, 2462.
43.
Fluorescent
probes for G-quadruplex structures
B. R. Vummidi, J.
Alzeer, N. W. Luedtke, ChemBioChem, 2013, 14, 540.
42.
Synthesis and
structure of a hydrogenated zinc hemiporphyrazine
S. M. Huber, G.
Mata, A. Linden, N. W. Luedtke, Chem. Commun.,
2013, 49, 4280.
41.
Stereoselective
N-glycosylation of 2-deoxythioribosides for fluorescent nucleoside synthesis
G. Mata, N. W.
Luedtke, J. Org. Chem., 2012, 77,
9006.
40.
Metabolic
labeling of DNA by purine analogs in vivo
A. B. Neef, F.
Samain, N. W. Luedtke, ChemBioChem, 2012, 13,
1750.
39.
Excitonic
luminescence of hemiporphyrazines
S. M. Huber, M. S.
Seyfried, A. Linden, N. W. Luedtke, Inorg. Chem., 2012,
51, 7032.
38.
Synthesis
of DNA interstrand crosslinks using a photocaged nucleobase (English)(German)
S. Hentschel, J.
Alzeer, T. Angelov, O. D. Schärer, N. W. Luedtke, Angew. Chemie Intl. Ed.,
2012, 51, 3466.
37.
Enantioselective
and label-free detection of oligopeptides via fluorescent indicator displacement
J. T. Ren, J. H.
Wang, J. Wang, N. W. Luedtke, E. K. Wang, Biosensors Bioelec. 2012,
35, 401.
36.
Site-specific
control of N7-metal coordination in DNA using a fluorescent purine derivative
A. Dumas, N. W.
Luedtke, Chem. Eur. J., 2012,
18, 245.
35.
Contribution
of G-Quadruplex probe design to improved detection of DNA sequences using
fluorescence
J. Ren, J. Wang, J.
Wang, N. W. Luedtke, E. Wang, Biosensors Bioelec., 2012,
31, 316.
35.
Dynamic
metabolic
labeling of DNA in vivo with arabinosyl nucleosides
A. B. Neef, N. W.
Luedtke, Proc. Natl. Acad. Sci. USA, 2011,
108, 20404.
33.
Fluorescence
properties of 8-(2-pyridyl)guanine "2PyG" as compared to 2-aminopurine
in DNA
A. Dumas, N. W.
Luedtke, ChemBioChem, 2011,
12, 2044.
32.
Highly
fluorescent guanine mimics for folding and energy transfer studies
A. Dumas, N. W.
Luedtke, Nucleic Acids Res., 2011,
39, 6825.
31.
Label-free
detection of nucleic acids by turn-ON and turn-OFF G-quadruplex-mediated
fluorescence
J. Ren, H. Qin, J.
Wang, N. W. Luedtke, E. Wang, Anal.
Bioanal. Chem. 2011, 2763.
30.
Cation-mediated
energy transfer in G-quadruplexes revealed by an internal fluorescent probe
A. Dumas, N. W.
Luedtke, J. Am. Chem. Soc. 2010,
132, 18004.
29.
G-quadruplex-modulated
fluorescence detection of potassium in a 3500-fold excess of sodium
ions
H. Qin, J. Ren, J.
Wang, N. W. Luedtke, E. Wang, Anal. Chem.
2010, 82, 8356.
28.
Multiple-turnover
isotopic labeling of Fmoc- and Boc-protected amino acids with oxygen isotopes
M. S. Seyfried, B.
S. Lauber, N. W. Luedtke, Org. Lett., 2010,
12, 104.
27.
pH-Mediated
fluorescence and G-quadruplex binding of amido phthalocyanines
J. Alzeer, N. W.
Luedtke, Biochemistry, 2010, 49,
4339.
26.
Cellular
uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS
G-quadruplexes
M. Paramasivam, A.
Membrino, S. Cogoi, J. Alzeer, N. W. Luedtke, L. E. Xodo, Chem.
Commun. 2010, 625.
25.
Guanidino
phthalocyanines as high affinity G-quadruplex fluorescent probes
J. Alzeer, B. R.
Vummidi, P. J. C. Roth, N. W. Luedtke, Angew. Chem. Intl. Ed.,
2009, 9362.
24.
An
efficient two-step synthesis of metal-free phthalocyanines using a zinc(II)
template
J. Alzeer, P. J. C. Roth, N.
W. Luedtke, Chem. Commun., 2009, 1970.
23.
Targeting
G-quadruplex DNA with Small Molecules
N. W.
Luedtke, Chimia, 2009, 63, 134.
22.
Surveying polypeptide and
protein domain conformation and association with FlAsH and ReAsH
N. W.
Luedtke, R. J. Dexter, D. B. Fired, A. Schepartz, Nat.
Chem. Biol. 2007,
779.
21.
Lanthanide-mediated
phosphoester hydrolysis and phosphate elimination from phosphopeptides
N. W. Luedtke, A.
Schepartz, Chem. Commun. 2005, 5426.
20.
A
rapid library screen for tailoring beta-peptide structure and function
J. A. Kritzer, N. W.
Luedtke, E. A. Harker, A. Schepartz, J. Am. Chem. Soc. 2005,
14584.
19.
On the electronic structure of ethidium
N. W. Luedtke, Q. Liu,
Y. Tor, Chem. Eur. J. 2005, 495.
18.
Chemical biology:
innovative solutions for diverse challenges
J. A. Kritzer, N. W.
Luedtke, Chem. Biol. 2005, 617.
17. RNA-selective modification by a
platinum(II) complex conjugated to amino- and
guanidinoglycosides
J. Boer, K. F. Blount, N. W. Luedtke, L. Elson-Schwab, Y.
Tor, Angew. Chem. Intl. Ed. 2005, 927.
16. Symmetrical
dinuclear complexes based on [Ru(dpq)2(phen)]2+ with high
DNA affinity
J. Aldrich-Wright, C. Brodie, E.
C. Glazer, N. W. Luedtke, Y. Tor, Chem. Commun. 2004, 1018.
15. Affinity
and specificity of aminoglycoside dimers and acridine conjugates to the HIV-1
Rev response element
N. W. Luedtke, Q. Liu, Y. Tor, Biochemistry, 2003,
11391.
14.
Cellular
uptake of aminoglycosides, guanidinoglycosides, and poly-arginine
N. W. Luedtke, P. Carmichael, Y.
Tor, J. Am. Chem. Soc., 2003, 12374.
13. Fluorescence-based
methods for evaluating the RNA affinity and specificity of HIV-1 Rev-RRE
inhibitors
N. W. Luedtke, Y. Tor, Biopolymers,
2003, 103.
12. The
DNA and RNA specificity of eilatin Ru(II) complexes as compared to eilatin and
ethidium
N. W. Luedtke, J. S. Hwang, E. C.
Glazer, D. Gut, M. Kol, Y. Tor, Nucleic Acids Res., 2003, 5732.
11. Synthesis,
photophysical properties, and nucleic acid binding of phenanthridinium
derivatives of ethidium
N. W.
Luedtke, Q. Liu, Y. Tor, Bioorg. Med. Chem., 2003, 5235.
10. Inhibition
of nuclear import mediated by the Rev-arginine rich motif by RNA molecules
K. Fineberg, T. Fineberg, A. Graessmann, N. Luedtke, Y.
Tor, D. Jans, A. Loyter, Biochemistry, 2003, 2625.
9. Eilatin
Ru(II) complexes display anti-HIV activity and enantiomeric diversity in the
binding of RNA
N. W. Luedtke, J. S. Hwang, E. C.
Glazer, D. Gut, M. Kol, Y. Tor, Chembiochem, 2002, 766.
8. 2-Aminopurine
as a real-time probe of enzymatic cleavage and inhibition of hammerhead
ribozymes
S. R. Kirk, N. W. Luedtke, Y. Tor,
Bioorg. Med. Chem., 2001, 2295.
7. A
simple conversion of amines into monosubstituted ureas in organic and aqueous
solvents
Q. Liu, N. W. Luedtke, Y. Tor, Tetrahedron
Lett., 2001, 1445.
6.
Development of a functional backbone cyclic mimetic of the HIV-1 Tat
arginine-rich motif
A. Friedler, D. Friedler, N. W. Luedtke, Y. Tor, A.
Loyter, C. Gilon, J. Biol. Chem., 2000, 23783.
5. Guanidinoglycosides:
A novel family of RNA ligands
N. W. Luedtke, T. J. Baker, M. Goodman, Y. Tor, J.
Am. Chem. Soc., 2000, 12035.
4.
A
novel solid-phase assembly for identifying potent and selective RNA ligands
N. W. Luedtke, Y. Tor, Angew.
Chem. Intl. Ed., 2000, 1788.
3.
Neomycin-acridine
conjugate: A potent inhibitor of Rev-RRE binding
S. R. Kirk, N. W. Luedtke, Y. Tor,
J. Am. Chem. Soc., 2000, 980.
2.
Synthesis and anti-HIV activity of guanidinoglycosides
T. J. Baker, N. W. Luedtke, Y.
Tor, M. Goodman, J. Org. Chem., 2000, 9054.
1. The
5'-GNC preference for mustard cross-linking is preserved in a restriction
fragment
J. T. Millard, N. W. Luedtke, R. J. Spencer, Anti-Cancer
Drug Des., 1996, 485.
Book Chapters
2.
Fluorescent
purine analogs for shedding light on DNA structure and function. In: Fluorescent
Analogs of Biolmolecular Building Blocks: Design and Application
A. Dumas, G. Mata, N. W. Luedtke, 2015, Wiley-VCH, in
press.
1.
Targeting HIV RNA with Small Molecules. In: DNA
and RNA Binders Vol. 1
N. W. Luedtke, Y. Tor, 2002, Wiley-VCH, 18-40.
Patents
7. Methods and products from the reaction of tetrazines with nucleic acids
bearing ethenyl aromatic groups
N. W. Luedtke, U. Rieder, 2014, PCT/EP provisional
application submitted.
6. Arabinofuranosyl
pyrimidine derivatives for incorporation of bioorthoginal functional groups into
DNA
N. W. Luedtke, A. B. Neef, 2011, PCT/EP
application 11187971.
5.
Preparation and uses of
guanidinium-modified
porphyrins and phthalocyanines
N. W. Luedtke, J. Alzeer, B. R. Vummidi, 2010, PCT
Intl. Appl. WO2010028780.
4.
8- and
6,8-substituted 2'-deoxyguanosines and uses thereof
N. W. Luedtke and A. D. Dumas, 2010, PCT Intl.
Appl. WO2010028781.
3. Preparation of phenanthridine
derivatives as anti-viral agents
Y. Tor and N. W. Luedtke, 2005, PCT Intl.
Appl.WO2005016343.
2.
Guanidinium
derivatives for improved cellular transport
Y. Tor and N. W. Luedtke, 2005, PCT Intl. Appl.
WO2005025513.
1.
Guanidinylation,
guanidinoglycosides, uses, and methods of assaying their
activity
M. Goodman, Y. Tor, T. Baker, and N. W. Luedtke, 2003,
U.S. 6,525,182 and 6,833,445.
Doctoral Theses
Fluorescent
Nucleosides for Probing Proton-Coupled DNA Folding in Real Time
Guillaume Mata, University of Zurich, Switzerland, 2014.
Clickable
Nucleoside Analogs for Dynamic Metabolic Labeling of Cellular DNA
Anne B. Neef, University of Zurich, Switzerland, 2013.
Cellular
Targets of Guanidino Phthalocyanines
Bala Yeshwanth Ram Vummidi, University of Zurich, Switzerland, 2013.
Synthesis
of DNA Interstrand Crosslinks Using a Photocaged Nucleobase
Sarah Hentschel, University of Zurich, Switzerland, 2013.
Design
and Synthesis of Planar Telomestatin Analogs
Martin S. Seyfried, University of Zurich, Switzerland, 2012.
8-Substituted-2'-Deoxyguanosines
as Internal Probes for DNA Folding and Energy Transfer
Anaelle Dumas, University of Zurich, Switzerland, 2011.
RNA Affinity and Specificity of Modified Aminoglycosides,
Metal Complexes, and Intercalating Agents
Nathan W. Luedtke, University of California, San Diego, 2003.
Masters' Thesis
Biphenyl
Boronic Acid Derivatives as Push-Pull Fluorescent Sensors of Carbohydrates
David
Oesch, Department of Chemistry, University of Zurich, 2014.
A New Approach for the Synthesis of 2-Oxazolines via in situ Desilylation
Marco
Brandstätter,
Institute of Organic Chemistry, University of Zurich, 2013.
Metal
Binding and Catalysis by Pyridine-Modified DNA
Olivia Schmidt, Institute of Organic Chemistry, University of Zurich, 2013.
Hemiporphyrazines:
Synthesis, Photophysical Properties and Rectivity
Sabrina M. Huber, Institute of Organic Chemistry, University of Zurich, 2012.
Synthesis and Evaluation of Cationic
Phthalocyanines as G-quadruplex Ligands
Raul Geraldo Pereira, Institute of Organic Chemistry, University of Zurich, 2011.
Diplom Thesis
Synthesis and Evaluation of Guanidino
Phthalocyanines for G-quadruplex Binding
Phillipe J. C. Roth, Institute of Organic Chemistry, University of Zurich, 2008.